Sin Nombre virus is the primary cause of hantavirus pulmonary syndrome in North America. It was identified in 1993 during the Four Corners outbreak, the first recognized HPS event in the Americas, and named for the lack of a clear toponym at the time of discovery (sin nombre = without a name).
| Reservoir host | Deer mouse (Peromyscus maniculatus) |
| Geographic range | United States, Canada, Mexico, particularly the U.S. Southwest, Pacific Northwest and Sierra Nevada |
| Disease syndrome | Hantavirus pulmonary syndrome (HPS) |
| Case fatality rate | ~36% |
| Vaccine | None licensed in most countries |
| Specific treatment | None. Supportive care. |
Sin Nombre virus is the primary cause of hantavirus pulmonary syndrome in North America. It was identified in 1993 during the Four Corners outbreak, the first recognized HPS event in the Americas, and named for the lack of a clear toponym at the time of discovery (sin nombre = without a name).
SNV does not transmit person-to-person. All known cases trace to direct or aerosol exposure to deer mouse excreta, typically in cabins, sheds, agricultural buildings, or rural homes where deer mice have been active.